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The CB1 receptor antagonist AM251 inhibited the exacerbation of hyperpermeability induced by the two endocannabinoids

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It is being investigated for treatment of various heterozygous mutations in LepR, POMC, or PCSK1 genes, and homozygous or heterozygous mutations in the steroid receptor coactivator-1 (SRC1) or SH2B adapter protein 1 (SH2B1) genes (125)